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Abstract
Commiphora foliacea Sprague and related species are renowned for the expensive perfumes, cosmetics, and aromatherapy due to its pleasant smell of essential oils used to promote relaxation, reduce stress, and improve memory loss. The chemical ingredients from the stem of C. foliacea Sprague essential oil (EO) were evaluated for GC-MS analysis, in vitro (antioxidant, antimicrobial, antidiabetic, and carbonic anhydrase-II (CA-II)) and in vivo (anti-analgesic and anti-inflammatory) studies. The EO encompasses 56 compounds contributed 93.58% of the total with leading compounds of camphene (14.02%) followed by eremophilene (11.46%). Maximum activity was depicted via DPPH and ABTS protocols compared to the standards. The EO was found effective against B. subtilis (gram-positive bacteria), while maximum antifungal inhibition was observed against A. parasiticus. The substantial antidiabetic and CA-II potential was noted compared with standards. The EO presented considerable potential against breast cancer (MDA-MB-231) and normal (MCF-10A) cell lines with an IC50 of 108.4 and 300 μg/mL, correspondingly and it has been assumed that the essential oil did not deliver much damage to the normal cell lines. Moreover, among the in vivo, the EO revealed the substantial anti-inflammatory potential to reduce paw edema with 63.81% inhibition in comparison to the standard Diclofenac. EO also depicted a significant reduction in analgesic potential (62.05%) compared to the standard aspirin. Furthermore, up to the best of our knowledge, this is the first report on the GC-MS analysis, in vitro, anti-analgesic, and anti-inflammatory potential of the EO isolated from the stem of C. foliacea.