Analysis of Polyethers by Isocratic HPLC with Universal Detectors IV. Comparison of Size Exclusion Chromatography and Liquid Adsorption Chromatography for the Analysis of Polypropylene glycols)

Abstract

Liquid adsorption chromotography (LAC) on an analytical scale, as well as on a semi-preparative scale is used for the analysis of polypropylene glycols), (PPG), and its performance for the determination of molecular mass distributions was compared with that of size-exclusion chromatography (SEC). Semi-preparative LAC provides monodisperse standards of PPG up to a molecular mass of 1400, which are used to establish an accurate SEC calibration. The influence of preferential solvation in LAC is studied and a correction method using two universal detectors (density and refractive index) is presented.

Key Words:

• Size exclusion chromotography
• HPLC of polymers
• density detector
• liquid adsorption chromatography
• polypropylene glycol)