Thymopentin Magnetic Molecularly Imprinted Polymers with Room Temperature Ionic Liquids as a Functional Monomer by Surface-Initiated ATRP

Abstract

Ionic liquids are also called “designer solvents.” In this article, we calculated the interaction energy of four ionic liquids with a template by molecular dynamics simulation. A simple approach was used to prepare biomacromolecule molecularly imprinted polymers for adsorbent and separation thymopentin (Tp5). In order to overcome intrinsic and increase structural selectivity, surface-initiated ATRP and ionic liquids (ILs) as functional monomer were used to prepare Fe3O4 molecularly imprinted polymers. Selective adsorption was applied to investigate the interactions between the polymers and lysine, phenylalanine, glutathione (GSH), and hemoglobin. The results demonstrated that Fe3O4 MIPs with 1-vinyl-3-ethyl acetate imidazolium chloride as functional monomer demonstrated high isolation and recognition of performance to the Tp5.

Keywords:

• Ionic liquids
• Magnetic
• Molecularly imprinted polymers
• Thymopentin

Notes

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/gpac.