Study of complexation between perrhenate ion and N-vinylpyrrolidone/N-vinylamine copolymers

ABSTRACT

Complexation of biologically active water-soluble flexible chain microassembled N-vinylpyrrolidone–N-vinylamine copolymers with ions was studied by complex chromatographic techniques (high-performance liquid chromatography and thin-layer chromatography). Constants of complex formation were evaluated (K_b = 4.6 × 10⁵). Hydrodynamic behavior and molecular radii of the prepared metal-polymeric compounds were evaluated by molecular optics and hydrodynamic methods [viscosimetry, sedimentation diffusion analysis, dynamic light scattering, and flow birefringence (Maxwell effect)]. No significant changes in hydrodynamic properties of metal-polymeric complexes as compared with those of the pure copolymers were observed. Thus, the suggested approach seems to be promising for producing noninvasive metal-polymeric complexes for biological purposes.

KEYWORDS:

• Chromatography
• copolymers
• dynamic light scattering
• flow birefringence
• metal-polymeric complexes
• sedimentation-diffusion analysis
• viscometry

Additional information

Funding

This research was supported by the Russian Foundation of Basic Research 16-03-00584, 15-03-08506, 15-03-09340, 6-33-01054, and grant program for young scientists FASIE (2016–2017).