Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations

This article refers to:

Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations

Comput Methods Biomech Biomed Engin. 2012 Aug 24. [Epub ahead of print]

In this paper, two minor but important issues need to be clarified to the reader:

• This paper credits Ramaswamy and others as having previously proposed the hypothesis that oscillatory shear stress caused by time-varying flow environments, triggered by cyclically bending geometries under flow states, plays a critical role in engineered tissue formation derived from bone marrow-derived stem cells and specifically, with regard to promoting the heart valve phenotype. Two references have been cited: Engelmayr et al. (2008) and Ramaswamy et al. (2010). However, the Engelmayr et al. (2008) reference is incorrect. The aforementioned hypothesis was only reported in the Ramaswamy et al. (2010) paper. The full reference to Ramaswamy et al. (2010) is as follows:

  Ramaswamy S, Gottlieb D, Engelmayr Jr. GC, Aikawa E, Schmidt DE, Gaitan-Leon DM, Sales VL, Mayer Jr. JE, Sacks MS. 2010. The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells. Biomaterials. 31(6):1114–1125.

• Equations (6) and (7) have not printed correctly in the paper. The correct forms of Equation (6) and (7) are as follows:

The issues as stated in (1) and (2) do not change the conclusions of this paper in any way. However, the authors sincerely apologise for any confusion these errors may have caused. For further clarifications, the reader may contact the corresponding author:

Address Correspondence to:

Sharan Ramaswamy, Ph.D.

Florida International University

Department of Biomedical Engineering

College of Engineering and Computing

10555 W. Flagler Street, EC 2612

Miami, FL 33174, USA

Tel: [phone]

Fax: [phone]

Email: [email protected]