Design space exploration of flow diverter hydraulic resistance parameters in sidewall intracranial aneurysms

Abstract

Intracranial aneurysms are nowadays treated with endovascular flow diverter devices to avoid sac rupture. This study explores how different linear and quadratic hydrodynamic resistance parameters reduce the flow in the sac for five patient-specific sidewall aneurysms.The 125 performed blood flow simulations included the stents using a Darcy-Forcheimer porous layer approach based on real-life stent characteristics. Time- and space-averaged velocity magnitudes were strongly affected by the linear coefficient with a power-law relationship. Quadratic coefficients alter the flow in a minor way due to the low-velocity levels in the aneurysm sac and neck region.

Keywords:

• Flow diverter
• porous medium
• computational fluid dynamics
• intracranial aneurysm
• hydrodynamic resistance

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethics approval statements

The internal review board of the National Institute of Mental Health, Neurology, and Neurosurgery (Budapest, Hungary) approved the study. Written consent was obtained from all patients.

Additional information

Funding

Levente Sándor and his work were supported by the Gedeon Richter Talentum Foundation in the framework of the Gedeon Richter Excellence PhD Scholarship. The study was supported by the European Commission through the H2020 project” In Silico World: Lowering barriers to ubiquitous adoption of In Silico Trials” (topic SC1-DTH-06-2020, grant ID 101016503). The study was also supported by the National Research, Development, and Innovation Fund of Hungary under Grant number TKP2021-EGA-02.