Tracer kinetics and metabolic models in medicine

Abstract

In the present paper, a survey of methods applied to the interpretation and evaluation of tracer kinetic data is given. For their mathematical description, both compartmental and non-compartmental models, such as the modified model of Sprinson and Rittenberg, the San Pietro–Rittenberg model, two models of the albumin metabolism and a 10-pool model of the N and protein metabolism were used. By means of single or multiple pulse, infusion and priming techniques, the N and protein metabolism in various metabolic states (e.g. healthy man, pathological and stress conditions, therapeutic treatments) were studied.

Keywords:

• computer calculations
• data processing
• kinetics
• man
• mathematical models
• medicine
• metabolism
• nitrogen-15
• proteins
• tracer techniques

Notes

^†Original version published in Vol. 150 of ‘ZfI-Mitteilungen’, Leipzig, Germany, 1989, pp. 181–204.