Effects of cafeteria diet and high fat diet intake on anxiety, learning and memory in adult male rats

Abstract

Objective: The effects of cafeteria and high fat diets were investigated on animal models of behavior.

Methods: Male Wistar rats were treated with Control (C), Cafeteria (CD) and High Fat (FD) diets and tested in the Elevated Plus-Maze (EPM) and Morris Water Maze (MWM) procedures. Body weight, length, abdominal circumference, retroperitoneal and epididymal adipose tissues were recorded. Physical parameters, weight of tissues, EPM, and MWM data were subjected to ANOVA followed by Newman–Keuls test (P < 0.05).

Results: There were no differences on weight and length parameters between CD and C rats up to 98 days of age. However, abdominal circumferences were higher in CD as compared to C at 35 and 70 days of age, respectively, the 5th and the 7th weeks. FD presented lower measures of weight and abdominal circumference; nevertheless there was an increase on those parameters at the end of the nutritional treatment. Even without an apparent weight gain of CD and FD these animals presented a greater accumulation of retroperitoneal and epididymal adipose tissues. In addition, CD and FD demonstrated behaviors that can suggest lower anxiety. CD showed a better learning performance and FD showed better recall of previous learned information in the memory retention test.

Discussion: According to those data it was concluded that hypercaloric diet ingestion was capable of triggering metabolic alterations and possibly lowering anxiety associated to learning or memory improvement on a spatial task.

Keywords:

• Cafeteria diet
• Fat diet
• Anxiety
• Learning
• Memory