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ABSTRACT
Introduction
The clinical symptoms and nutritional status of patients with Parkinson's disease (PwP) are interrelated, and the clinical outcomes in malnourished patients are often poor. Only a few studies have reviewed the prevalence of malnutrition and nutrition-related risk factors in PwP.
Objective
To explore the prevalence of malnutrition/ malnutrition risk among PwP, and estimate nutrition-related risk factors.
Methods
PubMed, EMBASE, and Cochrane Library were systematically searched. Literatures published between 1 January 1995 and 1 November 2020, subjects were patients with idiopathic PD underwent Mini Nutritional Assessment (MNA) were included.
Result
Sixteen articles, including 1650 PwP from 13 countries/regions, were included in the meta-analysis. The prevalence of malnutrition and malnutrition risk were 8.8% (Confidence interval [CI] 95%, 5.3%–12.2%) and 35.3% (CI 95%, 29.0%–41.7%), and the prevalence of nutritional disorders was 42.3% (CI 95%, 33.7%–51%). The prevalence of malnutrition in developing countries was higher than that in the developed countries. Meta-analysis reveals there were significant differences in the course of the disease (0.88 years; 95% CI, 0.26–1.50), levodopa equivalent daily dose (LEDD; 60.77 mg/day; 95% CI, 2.7–118.8), Hoehn and Yahr (H&Y) staging (0.323; CI 95%, 0.164–0.482), and unified Parkinson's disease rating scale (UPDRS) scores (total: 13.66, CI 95%: 10.57–16.75 and part III: 5.52, CI 95%: 3.79–7.25) between normal and nutritional disorder groups.
Conclusions
Malnutrition/malnutrition risk prevalence in PwP are high. The duration of the disease, LEDD, H&Y staging, and UPDRS score (part III and total) may be nutrition-related risk factors in PwP.
Acknowledgments
Thanks a lot for the excellent editorial job,which was performed by professional editors at Editage, a division of Cactus Communications, in cooperation with Taylor & Francis Group.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
The data used to support the findings of this study are available from the corresponding author upon request.
Additional information
Notes on contributors
Ji Fu
Ji Fu, MD
Email: [email protected]
2019-Now Attending, Department of Clinical Nutrition, Peking Union Medical College Hospital
2016-2019 Fellow, Department of Neurosurgery, Peking Union Medical College Hospital
2012-2016 Resident, Department of Surgery, Peking Union Medical College Hospital
2004-2012 Peking Union Medical College (Medical Doctor, Clinical Medicine)
Zhuo Li
Zhuo Li
Email: [email protected]
2018-2021 Peking Union Medical College Master (Major: Nutrition and food hygiene)
2013-2018 Jilin University Bachelor (Major: Preventive Medicine)
Fang Wang
Fang Wang
Email: [email protected]
2017-Now Resident, Department of Clinical Nutrition, Peking Union Medical College Hospital
2014-2017 Peking Union Medical College Hospital internal medicine training
2012-2014 Syracuse University (major: Clinical nutrition);
2007-2012 Tianjin Medical University (major: Medicine)
Kang Yu
Yu Kang, MD, Professor of Clinical Nutrition
Email: [email protected]
Address: Peking Union Medical College Hospital, Beijing 100730, CHINA
Director, Department of Clinical Nutrition and Department of Health Medicine, Peking Union Medical College Hospital, Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS);
President, Clinical Nutrition Society of Chinese Medical Doctor Association (CMDA);
President, Oncology Nutrition Society of Chinese Nutrition Society (CNS);
President, Clinical Nutrition Society of Beijing Medical Association.