Protective effect of resveratrol and tannic acid combination on aluminium chloride induced neurotoxicity in rats

ABSTRACT

Objective

Alzheimer’s disease is a progressive neurodegenerative disease and one of the most common causes of dementia. Despite recent advancements, there exists an unmet need for a suitable therapeutic option. This study aimed to evaluate the protective effects of the combination of resveratrol (20 mg/kg/day p.o.) and tannic acid (50 mg/kg/day p.o.) to reduce aluminium trichloride-induced Alzheimer’s disease in rats.

Methods

Wistar rats weighing 150–200g were administered with aluminium chloride (100 mg/kg/day p.o.) for 90 days to induce neurodegeneration and Alzheimer’s disease. Neurobehavioral changes were assessed using novel object recognition test, elevated plus maze test, and Morris water maze test. Histopathological studies were performed using H&E stain and Congo Red stains to check amyloid deposits. Further oxidative stress was measured in brain tissue.

Results

Aluminium trichloride treated negative control group showed cognitive impairment in the Morris water maze test, novel object recognition test, and elevated plus maze test. Further, the negative control group showed significant oxidative stress, increase amyloid deposits, and severe histological changes. Treatment with the combination of resveratrol and tannic acid showed significant attenuation in cognitive impairment. The oxidative stress markers and amyloid plaque levels were significantly attenuated with the treatment.

Conclusion

The present study indicates the beneficial effects of resveratrol-tannic acid combination in AlCl₃ induced neurotoxicity in rats.

KEYWORDS:

• Alzheimer’s disease
• neurodegeneration
• amyloid plaque
• resveratrol
• tannic acid

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data that support the findings of this study are available on request from the corresponding author.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.

Notes on contributors

Anisha Bhounsule

Anisha Bhounsule, M. Pharm is a post-graduate from Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy.

Lokesh Kumar Bhatt

Lokesh Kumar Bhatt, Ph. D. is an Associate Professor of Pharmacology at Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy.