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Journal of Asian Natural Products Research Volume 12, 2010 - Issue 7
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Original Articles

New isoprenylated flavonoids and cytotoxic constituents from Artocarpus tonkinensis

Jian-Ping Ma Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, China
,
Xin Qiao Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, China
,
Shu Pan Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, China
,
Hong Shen Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, China
,
Guo-Fu Zhu School of Chinese Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
&
Ai-Jun Hou Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, ChinaCorrespondence[email protected]
Pages 586-592 | Received 19 Jan 2010, Accepted 13 Apr 2010, Published online: 13 Jul 2010
 
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Abstract

Two new isoprenylated flavonoids, artotonins A and B (1 and 2), along with 13 known compounds (3–15), were isolated from the roots of Artocarpus tonkinensis A. Chev. ex Gagnep. The structures were elucidated by spectroscopic methods. Cyclocommunol (6), isocyclomulberrin (7), cudraflavone C (11), and morusin (13) exhibited cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines.

Acknowledgement

This study was financially supported by the National Natural Science Foundation of China (30572247) and the Key National Scientific and Technological Program ‘Major New Drug Development’ of the Ministry of Science and Technology of the PR China (No. 2009ZX09301-011).

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