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Journal of Asian Natural Products Research Volume 12, 2010 - Issue 6: Special issue dedicated to the memory of Professor Xiao-Tian Liang
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Original Articles

Chemical constituents of the stem bark of Morus cathayana

Original Article

Gang Ni The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Qing-Jian Zhang The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Ying-Hong Wang The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Ruo-Yun Chen The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Zhong-Fei Zheng The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
&
De-Quan Yu The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, ChinaCorrespondence[email protected]
Pages 505-515 | Received 11 Nov 2009, Accepted 26 Apr 2010, Published online: 15 Jun 2010
 
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Abstract

Phytochemical investigation of the stem bark of Morus cathayana led to the isolation and identification of six new compounds, cathayanons F–J (1–5) and cathayanin A (6), and two known compounds, cathayanins B–C (7–8). Their structures were elucidated by spectroscopic methods. Compounds 1, 2, 3, 5, and 7 exhibited weak activities against five human cancer cell lines, with IC50 values ranging from 4.7 to 9.8 μg/ml.

Acknowledgements

This research was supported by the National Natural Science Foundation of China (No. 20432030), the Basic Scientific Research Foundation of the Central Government of China (No. 2006QN04), and the Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education.

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