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Journal of Asian Natural Products Research Volume 12, 2010 - Issue 6: Special issue dedicated to the memory of Professor Xiao-Tian Liang
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Original Articles

Dibenzocyclooctadiene lignans from the fruits of Schisandra wilsoniana and their anti-HIV-1 activities

Original Article

Guang-Yu Yang State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China; Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming, 650106, China
,
Yin-Ke Li Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming, 650106, China; School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming, 650031, China
,
Rui-Rui Wang Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China
,
Wei-Lie Xiao State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, ChinaCorrespondence[email protected]
,
Liu-Meng Yang Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China
,
Jian-Xin Pu State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China
,
Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China
&
Han-Dong Sun State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, ChinaCorrespondence[email protected]
 show all
Pages 470-476 | Received 05 Feb 2010, Accepted 28 Mar 2010, Published online: 15 Jun 2010
 
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Abstract

Three new dibenzocyclooctadiene lignans, wilsonilignans A–C (1–3), together with nine known ones, were isolated from the fruits of Schisandra wilsoniana. The structures of 1–3 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1–3 were also evaluated for their anti-HIV-1 activities and showed bioactivity with EC50 values of 3.26, 6.18, and 2.87 μg/ml, respectively.

Acknowledgements

This project was supported financially by the NSFC (Nos 30830115 and 20802082), funds from the Chinese Academy of Sciences (‘Xibuzhiguang’ to W.-L.X. and No. KSCX1-YW-R-24), 973 programs (Nos 2009CB522300 and 2009CB940900), and the Young Academic and Technical Leader Rising Foundation of Yunnan Province (2006PY01-47).

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