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Abstract
A new ganoderic acid (GA), 7-O-ethyl ganoderic acid O (GA-O) (1), together with two known compounds, GA-T (2) and GA-Me (3), was isolated and purified from fermented mycelia of Ganoderma lucidum. The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data (HR-MS, IR, UV, 1D and 2D NMR) as 3α,15α,22-triacetoxy-7α-ethoxy-5α-lanost-8,24E-dien-26-oic acid. The new compound was found to contain a rare ethoxyl group at C-7. In addition, its cytotoxicity against 95D and HeLa human cancer cell lines was also evaluated.
Acknowledgements
Financial support from the National Natural Science Foundation of China (NSFC Project Nos 20776084 and 30821005), the National High Technology R&D Program (863 Project No. 2007AA021506), Shanghai Science & Technology Commission (Project No. 08DZ1971900), and the Shanghai Leading Academic Discipline Project (Project Nos B203 and B505) are gratefully acknowledged. The authors express their appreciation to Prof. Shuang-Jun Lin and Dr Jie-Li Wu for their kind help in spectral analysis.