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Original Articles

C28 sterols with a cyclopentane ring at C-22 and 26 from cape gooseberry (berries of Physalis pubeacens L.)

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Pages 752-759 | Received 08 Mar 2010, Accepted 28 May 2010, Published online: 13 Sep 2010
 

Abstract

Two new C28 sterols with a cyclopentane ring at C-22 and 26, alkesterol A (1) and alkesterol B (2), along with β-sitosterol (3), were isolated from the berries of Physalis pubeacens L. (cape gooseberry). The structures of the new compounds were established by HR-EI-MS, 1D and 2D (1H–1H COSY, HSQC, HMBC) NMR experiments. The known compound was identified by comparison of spectral data with published references. The two new compounds showed some cytotoxic activities by MTT assay.

Acknowledgements

This paper was funded by the National Sciences Foundation of China (No. 30873362) and Pre-research Project of Soochow University. We want to express our thanks to Mrs Li-Ping Shi in the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences for the determination of NMR spectral data.

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