A new diimide derivative from the co-culture broth of two mangrove fungi (strain no. E33 and K38)

Abstract

A new diimide derivative, named ( − )-byssochlamic acid bisdiimide (1), was isolated from the mixed broth of two mangrove fungi (strain no. K38 and E33) from the South China sea coast. The structure of 1 was determined by comprehensive spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) and semi-synthesis. Primary bioassays showed that 1 had weak cytotoxic activity against Hep-2 and HepG2 cells.

Keywords:

• mangrove fungi
• mixed fermentation
• ( − )-byssochlamic acid bisdiimide
• cytotoxic
• semi-synthesis

Acknowledgements

We wish to acknowledge the financial support from the 863 Foundation of China (2006AA09Z422, 2006AA09Z419), the Natural Science Foundation of Guangdong Province (9451064201003751, 9151027501000055) of China and the Key Academic Program of the Third Phase ‘211 Project’ of South China Agricultural University (2009B010100001).