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Journal of Asian Natural Products Research Volume 12, 2010 - Issue 10
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A new diarylheptanoid from the bark of Alnus japonica

Nguyen Huu Tung College of Pharmacy, Chungnam National University, Daejeon, 305-764, South Korea
,
Jeong Chan Ra RNL BIO Co., Ltd, 1596-7 Nakseongdae-Dong, Gwanak-Gu, Seoul, South Korea
,
Dong Hwan Sohn Department of Pharmacy, Institute of Pharmaceutical Research Development, Wonkwang University, Iksan, 570-749, South Korea
&
Young Ho Kim College of Pharmacy, Chungnam National University, Daejeon, 305-764, South KoreaCorrespondence[email protected]
Pages 921-924 | Received 28 May 2010, Accepted 06 Jul 2010, Published online: 28 Sep 2010
 
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Abstract

A new diarylheptanoid, epihirsutanonol (1), was isolated from the bark of Alnus japonica, along with two known ones (2 and 3). Their structures were elucidated on the basis of extensive spectroscopic evidence. The new compound 1 showed significant hepatoprotective activity on the basis of t-butylhydroperoxide-induced hepatocyte injury in vitro assay.

Acknowledgements

This study was supported by the Priority Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093815), Republic of Korea.

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