New myrsinane-type diterpenoids from Euphorbia aellenii Rech. f. with their immunomodulatory activity

Abstract

Two new 14-desoxo-10, 18-dihydromyrinsol diterpenoids (1 and 2) were isolated and characterized from the cytotoxic chloroform fraction of Euphorbia aellenii Rech. f. (Euphorbiaceae). The structures of the new compounds were elucidated by spectroscopic methods and their immunomodulatory properties were evaluated by T-cell proliferation and phagocyte chemiluminescence assays.

Keywords:

• Euphorbia aellenii
• 10,18-dihydromyrinsol diterpenes
• myrsinane
• immunomodulatory effect

Acknowledgements

This paper is part of the thesis of Syed Mustafa Ghanadian submitted for the fulfillment of the degree of doctor of philosophy in Pharmacognosy in Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. One of the authors (S.M.G) is grateful to the H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi for their scientific and financial supports.