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Journal of Asian Natural Products Research Volume 13, 2011 - Issue 3
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Original Articles

A new rearranged abietane diterpenoid from Clerodendrum kaichianum Hsu

Ming-Feng Xu College of Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou, 310035, China
,
Lian-Qing Shen College of Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou, 310035, ChinaCorrespondence[email protected]
,
Kui-Wu Wang College of Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou, 310035, China
,
Qi-Zhen Du College of Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou, 310035, China
&
Nan Wang College of Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou, 310035, China
Pages 260-264 | Received 06 Oct 2010, Accepted 22 Dec 2010, Published online: 15 Mar 2011
 
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Abstract

A new abietane diterpenoid, (3S,16R)-12,16-epoxy-3,6,11,14,17-pentahydroxy-17(15 → 16)-abeo-5,8,11,13-abietatetraen-7-one (1), was isolated from the stems of Clerodendrum kaichianum Hsu, together with four known diterpenoids. The structures of the isolated compounds were assigned on the basis of their NMR spectra including 2D NMR techniques such as COSY, HMQC, and HMBC experiments, and were compared with those of the literature data. This new compound showed significant cytotoxicity against the HL-60 and A-549 tumor cell lines.

Acknowledgements

This research was supported by a fund (2006C12044) from the Department of Science and Technology of Zhejiang Province and a grant from Zhejiang Provincial Natural Science Foundation of China (Y4090121).

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