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Journal of Asian Natural Products Research Volume 13, 2011 - Issue 3
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Original Articles

Two new compounds from an endophytic fungus Aspergillus sp. HS-05

Lin Zhang School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Gang Chen School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Hong-Hua Wu School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Xuan Lu School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Yue-Hu Pei School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Xin Wu School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Bo Pan School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China
,
Hui-Ming Hua School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China
&
Jiao Bai School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaCorrespondence[email protected]
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Pages 225-229 | Received 25 Oct 2010, Accepted 22 Dec 2010, Published online: 15 Mar 2011
 
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Abstract

Two new compounds, N-[4′-hydroxy-(E)-cinnamoyl]-l-tyrosine methyl ester (1) and methyl 4-methoxy-3-(3′-hydroxy-2′-methyl)propionyloxy-benzoate (2), were isolated from EtOAc extract of the fermentation broth of the endophytic fungus Aspergillus sp. HS-05. Their structures were elucidated by NMR, IR, UV, MS, and CD methods. Compounds 1 and 2 showed no anticancer activities against HL-60 cell lines (both of IC50>100 μM) in vitro.

Acknowledgements

This work was supported by the Ministry of Science and Technology of China ‘Hi-Tech Research and Development Program of China’ (863 project), under Contract No. 2007AA09Z435, and ‘the National Natural Science Foundation of China’ under Contract No. 40776098.

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