Two new 5,8-quinoflavans from the leaf of Ilex centrochinensis

Abstract

Two new 5,8-quinoflavans were isolated from the leaf of Ilex centrochinensis, and their structures were elucidated as (2R)-7,3′,4′-trimethoxy-5,8-quinoflavan and (2S)-7-methoxy-4′-hydroxy-5,8-quinoflavan on the basis of spectroscopic methods, especially 1D and 2D NMR, CD, and mass spectral analyses. Both of them exhibited weak cytotoxic activity against HuH7 cell lines and no cytotoxic activity against CaCO-2 cell lines.

Keywords:

• Ilex centrochinensis
• (2R)-7,3′,4′-trimethoxy-5,8-quinoflavan
• (2S)-7-methoxy-4′-hydroxy-5,8-quinoflavan
• cytotoxic activity

Acknowledgements

This work was financially supported by the opening fund of Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Huazhong University of Science and Technology. We are grateful to pharmacist C.R. Wang (Enshi Food and Drug Administration, Hubei Province, China) for medicinal material collection.