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Journal of Asian Natural Products Research Volume 13, 2011 - Issue 5
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Original Articles

Synthesis and antitumor activity of novel podophyllotoxin derivatives against multidrug-resistant cancer cells

Yong-En Guo Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, ChinaCorrespondence[email protected]
,
Hong Chen Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin, 300162, China; Graduate School of Tianjin Medical University, Tianjin, 300070, ChinaView further author information
,
Song Zuo Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin, 300162, China; Graduate School of Tianjin Medical University, Tianjin, 300070, China
,
Dai-Lin Liu Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin, 300162, China
,
Yan-Ling Lu Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin, 300162, China; Graduate School of Tianjin Medical University, Tianjin, 300070, China
,
Jing-Jing Lv Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin, 300162, China
,
Shao-Peng Wen Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China
&
Tong-Cun Zhang Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, ChinaView further author information
 show all
Pages 417-424 | Received 19 Dec 2010, Accepted 02 Mar 2011, Published online: 29 Apr 2011
 
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Abstract

Seven novel 4β-N-substituted podophyllotoxin derivatives with indole rings were prepared and evaluated for cytotoxicity against human cancer cell lines HeLa, KB, KBV, K562, and K562/AO2. Most of them demonstrated improved antitumor activity and weak multidrug resistance compared to the drugs currently available.

Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (No. 30873363), the Key Project of Science Foundation of Tianjin (09ZCKFNC01200), and the Program of Science Foundation of Tianjin (08JCYBJC070000).

Notes

1. Email: [email protected]

2. Email: [email protected]

Additional information

Notes on contributors

Hong Chen

1

Tong-Cun Zhang

2

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