Chemical constituents from the roots of Feroniella lucida

Abstract

A new furanocoumarin named lucidafuranocoumarin A (7) together with 13 known coumarins (1–6, 8–14) and four known alkaloids (15–18) was isolated from the roots of Feroniella lucida. Their structures were elucidated on the basis of spectroscopic analysis. Some of the isolates were evaluated for their biological activities, and compound 18 showed strong cytotoxicity against KB (IC₅₀ = 0.637 μg/ml) and NCI-H187 (IC₅₀ = 0.094 μg/ml) human cancer cell lines, antimalarial activity against Plasmodium falciparum (IC₅₀ = 0.336 μg/ml), and antituberculosis activity against Mycobacterium tuberculosis (MIC = 6.25 μg/ml).

Keywords:

• Feroniella lucida
• Rutaceae
• cytotoxic activity
• antimalarial activity
• antituberculosis

Acknowledgements

We would like to thank Thailand Research Fund (TRF) through the Royal Golden Jubilee PhD program for a scholarship to TS (Grant No. PHD/0004/2553), Mae Fah Luang University, and National Research Council of Thailand (NRCT) for financial supports. We are grateful to Mr Nitirat Chimnoi, Chulabhorn Research Institute, Bangkok, for recording the MS spectral data and also thankful to Assoc. Prof. Dr Uma Prawat and Ms. Nareerat Thongtip, Phuket Rajabhat University, for recording the NMR spectral data. The Bioassay Research Facility of BIOTEC (Thailand) is also gratefully acknowledged for biological activity tests.