Abstract
A new drimane sesquiterpenoid glycoside, named 7-drimen-3β,11-diol 3-O-β-d-glucopyranoside, was isolated from the 95% EtOH extract of the seeds of Antiaris toxicaria (Pers.) Lesch. The chemical structure was completely elucidated using a combination of 1D and 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analysis. The compound showed inhibitory activities toward methicillin-resistant Staphylococcus aureus (MRSA), chronic myelogenous leukemia (K562), and human hepatoma (SMMC-7721) cell lines.
Acknowledgements
This research was financially supported by National Basic Research Program of China (No. 2009CB125900), National Natural Science Foundation of China (No. 30860345), and National Nonprofit Institute Research Grant of CATAS-ITBB (No. ITBBZD0744).