Two new dammarane monodesmosides from Centella asiatica

Abstract

Two new dammarane monodesmosides centellosides A (1) and B (2), and two new natural products ginsenosides Mc (10) and Y (11), together with 11 known compounds (3–9 and 12–15) reported for the first time from this genus, were isolated from the whole plants of Centella asiatica. All structures were elucidated by spectroscopic techniques and chemical methods, and compared with literature values. All the isolated compounds were evaluated in vitro for cytotoxicity.

Keywords:

• Centella asiatica
• centelloside
• ginsenoside
• cytotoxicity

Acknowledgement

This work was financially sponsored by the National Science and Technology Funding ‘Created a Significant New Drug,’ China (Grant No. 2009ZX09301-007).