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Journal of Asian Natural Products Research Volume 13, 2011 - Issue 9
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Original Articles

Conversional synthesis and cytotoxic evaluation of novel taxoid analogs

Lei Song Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, 610041, China
,
Qiao-Hong Chen Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, 610041, China
,
Xue-Ke She Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, 610041, China
,
Xiao-Guang Chen Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, 100050, China
&
Feng-Peng Wang Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, 610041, ChinaCorrespondence[email protected]
Pages 787-798 | Received 02 Apr 2011, Accepted 23 May 2011, Published online: 10 Aug 2011
 
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Abstract

Four novel taxoid analogs were conversionally synthesized from the C19-diterpenoid alkaloid deltaline, and their cytotoxic activities were evaluated against a small panel of cancer cell lines.

Acknowledgement

We are grateful to the National Natural Science Foundation of China (No. 30873147) for financial support of this research.

Notes

†Present address: Key Laboratory of Modern Chinese Medicines (China Pharmaceutical University), Ministry of Education, Tongjia lane, Nanjing 210009, China.

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