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Journal of Asian Natural Products Research Volume 13, 2011 - Issue 10
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Original Articles

A new furanoxanthone from the stem bark of Calophyllum inophyllum

Gwendoline Cheng Lian Ee Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, MalaysiaCorrespondence[email protected]
,
Siau Hui Mah Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
,
Mawardi Rahmani Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
,
Yun Hin Taufiq-Yap Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
,
Soek Sin Teh Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
&
Yang Mooi Lim Faculty of Medicine and Health Science, Universiti Tunku Abdul Rahman, 43000, Kajang, Selangor, Malaysia
Pages 956-960 | Received 13 Apr 2011, Accepted 22 Jun 2011, Published online: 05 Oct 2011
 
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Abstract

The stem bark extracts of Calophyllum inophyllum furnished one new furanoxanthone, inophinnin (1), in addition to inophyllin A (2), macluraxanthone (3), pyranojacareubin (4), 4-hydroxyxanthone, friedelin, stigmasterol, and betulinic acid. The structures of these compounds were determined by spectroscopic analysis of 1D and 2D NMR spectral data (1H, 13C, DEPT, COSY, HMQC, and HMBC) while EI-MS gave the molecular mass. The new xanthone, inophinnin (1), exhibited some anti-inflammatory activity in nitric oxide assay.

Acknowledgements

The authors acknowledge financial support from UPM and MOSTI under the Agri Science Fund. Special thanks go to Assoc. Prof. Dr Jegak Uli for collection of plant samples and Mr Yong Yoke Keong for anti-inflammatory assay screening.

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