Abstract
Two new α,β-unsaturated γ-lactones, myrolactones A (1) and B (2), were characterized from the culture broth of the Myrothecium sp. IFB-E106 isolated from the roots of Vatica mangachapoi Blauco. The absolute configuration was determined by the computational electronic circular dichroism approach. Myolactone B showed neuraminidase inhibitory activity with the IC50 value of 13.95 μM.
Acknowledgements
The work was co-supported financially by grants from NSFC (30821006 and 90813036) and MOST (2009ZX09501-013).