Abstract
Five new 9,10-anthraquinones (1–5) were isolated from an ethanol extract of the roots of Knoxia valerianoides. Their structures including absolute configuration of 1 were determined by spectroscopic analysis. Compounds 4 and 5 showed moderate activity against nitrogen oxide production in macrophages induced by lipopolysaccharide, at 10− 5 M, with inhibition ratios of 50.4 ± 3.6 and 41.7 ± 2.1%, respectively.
Acknowledgements
Financial support from the National Natural Sciences Foundation of China (NNSFC; Grant Nos 30825044 and 20932007) and the National Science and Technology Project of China (No. 2009ZX09311-004) is acknowledged.