Iridoids from the roots of Valeriana jatamansi

Abstract

Two new iridoids, jatamanvaltrates N (1) and O (2), together with four known compounds (3–6), were isolated from the roots of Valeriana jatamansi. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESI-MS, HR-ESI-MS, 1D, and 2D NMR) and by comparison of their NMR spectral data with those of related compounds. All the isolated compounds were evaluated for their neuroprotective effects, and only compound 1 showed weak neuroprotective activities.

Keywords:

• Valerianaceae
• Valeriana jatamansi
• iridoid
• jatamanvaltrate N
• jatamanvaltrate O

Acknowledgements

The project was financially supported by the Natural Science Foundation of China (No. 30801432) and the Natural Science Foundation of Tianjin (No. 09JCZDJC22000), China.