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Journal of Asian Natural Products Research Volume 13, 2011 - Issue 12
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Original Articles

Sorbicins A and B, new urease and serine protease inhibitory triterpenes from Sorbus cashmiriana

Mehdi Hassan Kazmi Department of Applied Chemistry, University of Karachi, Karachi, 75270, Pakistan
,
Itrat Fatima H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan
,
Abdul Malik H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, 75270, PakistanCorrespondence[email protected]
,
Lubna Iqbal Pharmaceutical Research Centre, PCSIR Laboratories Complex Karachi, Karachi, 75280, Pakistan
,
Mehreen Latif Pharmaceutical Research Centre, PCSIR Laboratories Complex Karachi, Karachi, 75280, Pakistan
&
Nighat Afza Pharmaceutical Research Centre, PCSIR Laboratories Complex Karachi, Karachi, 75280, Pakistan
Pages 1081-1086 | Received 24 Jun 2011, Accepted 20 Sep 2011, Published online: 25 Nov 2011
 
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Abstract

Two new lupene-type triterpenes, sorbicins A (1) and B (2), have been isolated from the chloroform-soluble fraction of the MeOH extract from the whole plant of Sorbus cashmiriana, and their structures were elucidated by spectroscopic techniques including 2D NMR. Both compounds displayed urease and α-chymotrypsin inhibitory potential.

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