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Original Articles

Effects of breviscapine on pulmonary inflammatory response and lung injury in children undergoing open heart surgery

, , , , , , & show all
Pages 270-275 | Received 12 Aug 2011, Accepted 21 Dec 2011, Published online: 14 Feb 2012
 

Abstract

This study examined the effects of breviscapine (1) on pulmonary inflammatory response and lung function in pediatric patients undergoing open heart surgery. Forty-five children (ASA II or III, aged 2–72 months) were randomly assigned to control group (saline, Group C), low dose 1 group (0.5 mg/kg, Group Bre0.5), and high dose 1 group (1.0 mg/kg, Group Bre1.0), 15 cases each group. Plasma concentrations of procalcitonin (PCT) and neutrophil elastase (NE) were measured and compared at different time points. Plasma concentrations of PCT and NE were increased after cardiopulmonary bypass (CPB) induction, and the concentrations were lower in 1-treated groups. The present results indicated that continuous infusion of 1 before the CPB suppressed the production of PCT and NE attenuated systemic inflammatory response, which could result in lung protective effect in children undergoing open heart surgery.

Acknowledgements

This work was financially supported by Science & Technology Projects from Science & Technology Bureau of WenZhou city (No. Y2005A088).

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