The synthesis of pennogenin 3-O-β-d-glucopyranosyl-(1 → 3)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-glucopyranoside

Abstract

Pennogenin 3-O-β-d-glucopyranosyl-(1 → 3)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-glucopyranoside, a monodesmosidic saponin isolated from Paris polyphylla Smith var. yunnanensis with promised antitumor activities, was firstly synthesized from glucoside thiol via nine steps and with 27% overall yield.

Keywords:

• pennogenin
• α-l-rhamnopyranoside
• β-d-glucopyranoside
• antitumor activity
• synthesis

Acknowledgements

This work was financially supported by the Scientific Research Fund of Sichuan Provincial Education Department (11205023).