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Journal of Asian Natural Products Research Volume 14, 2012 - Issue 5
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Original Articles

Highly efficient synthesis and antitumor activity of monosaccharide saponins mimicking components of Chinese folk medicine Cordyceps sinensis

Zhen-Yuan Zhu Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, ChinaCorrespondence[email protected]
,
Qiang Yao Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China
,
Yang Liu Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China
,
Chuan-Ling Si Tianjin Key Laboratory of Pulp & Paper, College of Material Science and Chemical Engineering, Tianjin University of Science and Technology, Tianjin, 300457, China
,
Jing Chen Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China
,
Nian Liu Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China
,
Hong-Yu Lian Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China
,
Li-Na Ding Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China
&
Yong-Min Zhang Université Pierre et Marie Curie-Paris 6, Institut Parisien de Chimie Moléculaire (UMR CNRS 7201), 4 place Jussieu, 75005, Paris, France
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Pages 429-435 | Received 05 Aug 2011, Accepted 23 Feb 2012, Published online: 20 Mar 2012
 
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Abstract

Ergosterol 3-O-β-d-glucopyranoside (1a) and ergosterol 3-O-β-d-galactopyranoside (1b) were highly efficiently synthesized and evaluated for their inhibitory activities against two tumor cell lines. The structures of these compounds were extensively confirmed by 1H, 13C NMR, IR, and HRMS. Compounds 1a and 1b exhibited interesting cytotoxic profiles. The antitumor activity of compound 1a was higher than that of 1b.

Acknowledgments

This work was financially supported by Program for Changjiang Scholars and Innovative Research Team in University (IRT1166), National Agricultural Innovation Project (No. 2011GB2A100009), Natural Science Foundation of Tianjin City (No. 09JCZDJC21800), the Foundation of Tianjin Educational Committee (No. 20090604), the Scientific and Technical Supporting Programs of Science and Technology Commission Foundation of Tianjin (No. 08ZCGHHZ00800), National Natural Science Foundation of China (NSFC, No. 31000279), and Recruited faculty research start-up foundation in Tianjin University of Science and Technology (No. 0200060).

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