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Journal of Asian Natural Products Research Volume 14, 2012 - Issue 6
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Original Articles

Two new sesquiterpene lactones from the supercritical fluid extract of Centipeda minima

Peng Wu Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China
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Xiao-Guang Li The Joint Laboratory for Brain Function and Health, Jinan University, Guangzhou, 510632, China
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Ning Liang Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China
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Guo-Cai Wang Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China
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Wen-Cai Ye Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China
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Guang-Xiong Zhou Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, ChinaCorrespondence[email protected]
&
Yao-Lan Li Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, ChinaCorrespondence[email protected]
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Pages 515-520 | Received 13 Oct 2011, Accepted 23 Feb 2012, Published online: 20 Mar 2012
 
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Abstract

Two new sesquiterpene lactones, minimolides G (1) and H (2), were isolated from the supercritical fluid extract of Centipeda minima. Their structures were elucidated on the basis of extensive analyses of spectroscopic data including IR, HR-ESI-MS, 1D and 2D NMR. Compounds 1 and 2 displayed inhibitory activity against human nasopharyngeal cancer cell line (CNE) with IC50 values of 61.4 and 28.7 μM, respectively.

Acknowledgments

This work was supported financially by the National Natural Science Foundation of China (No. 30840099) and the Natural Science Foundation of Guangdong, China (No. 9151064101000027).

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