Two new quaternary protoberberine alkaloids from Corydalis yanhusuo

Abstract

Two new quaternary protoberberine alkaloids, namely corydayanine (1) and yanhusuine (2), were isolated from the tubers of Corydalis yanhusuo. On the basis of extensive chemical and spectroscopic evidences, especially 1D and 2D NMR and HRMS experiments, their structures were elucidated as 5,6-dihydro-3,9-dihydroxy-2,10-dimethoxy-13-methyl-dibenzo[a,g] quinolizinium alkaloid and 5,6-dihydro-12-hydroxy-2,3,9-trimethoxy-13-methyl-dibenzo[a,g] quinolizinium alkaloid, respectively.

Keywords:

• Corydalis yanhusuo
• Papaveraceae
• quaternary protoberberine alkaloid
• corydayanine
• yanhusuine

Acknowledgments

We thank Associate Prof. L. Ma for the sample collection and authentication. This work was financially supported by grants from the National Key Project for Basic Research of Science and Technology (2007FY130100), and National Science and Technology Project of China (2011ZX09307-002-01).