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Journal of Asian Natural Products Research Volume 14, 2012 - Issue 5
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Original Articles

Two new C13-norisoprenoids from Solanum lyratum

Xi-Dian Yue College of Food Science and Technology, Ocean University of China, Qingdao, 266003, China
,
Gui-Wu Qu College of Food Science and Technology, Ocean University of China, Qingdao, 266003, China
,
Ba-Fang Li College of Food Science and Technology, Ocean University of China, Qingdao, 266003, China
,
Chang-Hu Xue College of Food Science and Technology, Ocean University of China, Qingdao, 266003, China
,
Gui-Sheng Li School of Pharmaceutical Science, Yantai University, Yantai, 264005, China
&
Sheng-Jun Dai School of Pharmaceutical Science, Yantai University, Yantai, 264005, ChinaCorrespondence[email protected]
Pages 486-490 | Received 08 Dec 2011, Accepted 18 Mar 2012, Published online: 24 Apr 2012
 
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Abstract

Two new C13-norisoprenoids, named lyratols E and F (1–2), were isolated from the whole plant of Solanum lyratum Thunb, and their structures were elucidated by extensive spectroscopic analyses. In vitro, two new compounds were found to show significant cytotoxicity against selected cancer cells including P-388 and HT-29.

Acknowledgments

This study was financially supported by the Natural Science Foundation of Shandong Province (No. ZR2009CZ004). The authors are grateful to Ms Hong Yu and Li Shen (School of Pharmaceutical Science, Yantai University) for the measurement of FAB-MS, HR-FAB-MS, UV, IR, and NMR spectra, respectively. The authors also gratefully acknowledge Mr Liang Ye (School of Pharmaceutical Science, Yantai University) for the bioactivity screenings.

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