A new acylated flavonoid glycoside from the flowers of Camellia nitidissima and its effect on the induction of apoptosis in human lymphoma U937 cells

Abstract

From the EtOH extract of the flowers of Camellia nitidissima Chi, a new acylated flavonoid glycoside, quercetin 7-O-(6″-O-E-caffeoyl)-β-d-glucopyranoside (1), has been isolated, together with three known flavonoids: quercetin (2), quercetin 3-O-β-d-glucopyranoside (3), and quercetin 7-O-β-d-glucopyranoside (4). Their structures were elucidated on the basis of spectroscopic analysis. Compound 1 was shown to inhibit proliferation and to induce apoptosis of human lymphoma U937 cells.

Keywords:

• Camellia nitidissima
• flavonoid glycoside
• cytotoxicity
• apoptosis

Acknowledgments

This work was financially supported in part by the Grant-in-Aid for Scientific Research (No. 81001621) from National Natural Science Foundation of China and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.

Notes

1. These authors contributed equally to this work.

Additional information

Notes on contributors

Xiao Peng

1

Da-Yong Yu

1