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Journal of Asian Natural Products Research Volume 14, 2012 - Issue 9
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Original Articles

Aquisiflavoside, a new nitric oxide production inhibitor from the leaves of Aquilaria sinensis

Xin-Bao Yang State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China; Beijing University of Chinese Medicines, Beijing, 100029, China; Xiyuan Hospital, China Academy of Chinese Sciences, Beijing, 100091, ChinaView further author information
,
Jie Feng State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, ChinaView further author information
,
Xiu-Wei Yang State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, ChinaCorrespondence[email protected]
,
Bo Zhao State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China
&
Jian-Xun Liu Beijing University of Chinese Medicines, Beijing, 100029, China; Xiyuan Hospital, China Academy of Chinese Sciences, Beijing, 100091, ChinaCorrespondence[email protected]
Pages 867-872 | Received 12 May 2012, Accepted 06 Jun 2012, Published online: 28 Aug 2012
 
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Abstract

A new flavonoid glycoside, named aquisiflavoside, was isolated from the leaves of Aquilaria sinensis (Lour.) Gilg, and its structure was elucidated by spectroscopic analyses. Aquisiflavoside was evaluated for the inhibition of nitric oxide (NO) production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and exhibited a potent inhibitory activity against NO production in a dose-dependent manner with an IC50 value of 34.95 μM.

Acknowledgment

This research was partly supported by the National Key Technology R&D Program of China (2011BAI07B08 and 2006BAI 06A01-02).

Notes

1. These authors contributed equally to this work.

Additional information

Notes on contributors

Xin-Bao Yang

1

Jie Feng

1

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