Fasciospyrinadine, a novel sesquiterpene pyridine alkaloid from a Guangxi sponge Fasciospongia sp.

Abstract

Fasciospyrinadine (1), a novel sesquiterpene pyridine alkaloid with a previously unreported skeleton featuring a monocyclicfarnesane moiety attached to a 3-methylenepyridine residue, was isolated from the sponge Fasciospongia sp. from Weizhou Island, Guangxi Autonomous Region. The structure and the relative stereochemistry of 1 were elucidated on the basis of extensive analysis of its 1D and 2D NMR spectroscopic techniques.

Keywords:

• sponge
• Fasciospongia sp.
• fasciospyrinadine
• sesquiterpene alkaloids

Acknowledgements

This research work was financially supported by the National Marine ‘863’ Projects (Nos 2011AA09070102 and SS2013AA090202) and Natural Science Foundation of China (Nos 81273430, 21072204, 81001397, 21162016, and 20862013). We are also grateful to Dr Ernesto Mollo for the collection of the animal material.

Notes

1. These authors contributed equally to the work.

Additional information

Notes on contributors

Zheng-Bao Zhao

1

Ji-Zheng Sun

1