Two new stemona alkaloids from Stemona tuberosa Lour.

Abstract

Two new pyrrolo[1,2-α]azepine-type stemona alkaloids, named as tuberostemonoxirine (1) and 9α-epi-tuberospironine (2), were isolated from the roots of Stemona tuberosa. The structures and relative configurations of new compounds were established on the basis of extensive spectroscopic evidences, especially 1D and 2D NMR and HR-MS experiments.

Keywords:

• Stemona tuberosa
• Stemonaceae
• alkaloids
• tuberostemonoxirine
• 9α-epi-tuberospironine

Acknowledgements

The authors thank associate Prof. L. Ma for the sample authentication. This work was financially supported by grants from National Science and Technology Project of China (No. 2011ZX09307-002-01; 2007FY130100).