Two new diterpenoids from Excoecaria acerifolia

Abstract

A new tigliane diterpenoid, acerifolin A (1), and a new isopimarane diterpenoid, acerifolin B (2), together with two known compounds, were isolated from Excoecaria acerifolia. Their structures were elucidated on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. All of the compounds were evaluated for cytotoxicity against five human cancer cell lines with cisplantin as a positive control.

Keywords:

• Excoecaria acerifolia
• diterpenoids
• cytotoxic activity
• Euphorbiaceae

Acknowledgments

This work was financially supported by the National Basic Research Program of China (973 Program Nos 2011CB915503 and 2009CB522303), the National Natural Science Foundation of China (Nos 90813004 and U0932602), projects from the Chinese Academy of Sciences (Nos 2009311211011 and 2009312311024), and the State Key Laboratory of Phytochemistry and Plant Resources in West China (No. P2010-ZZ05).