Two new compounds from the metabolites of a marine-derived actinomycete Streptomyces cavourensis YY01-17

Abstract

Our current marine natural product program investigated the second metabolites of an actinomycete Streptomyces cavourensis YY01-17 originating from the Antarctic ecological niche to discover potential antitumor chemical entities. Two new compounds, along with a known compound, were isolated from the ethyl acetate extract of the fermentation broth of the marine-derived actinomycete, and their structures were elucidated, respectively, as 2(S)-3′-hydroxybutan-2′-yl 2-hydroxypropanoate (1), (E)-3-hydroxy-2,4-dimethylhept-4-enamide (2), and 2-hydroxy-3-methylbutanoic acid (3) on the basis of spectroscopic data interpretation.

Keywords:

• marine actinomycete
• Streptomyces cavourensis
• amide

Acknowledgements

This work was financially supported by the National High Technology Research and Development Program (863 Program) of China (2011AA10A202-2), National Key Technologies R&D Program (2011BAE06B04), and the National Natural Science Foundation of China (40976104).