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Journal of Asian Natural Products Research Volume 15, 2013 - Issue 3
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Original Articles

Novel microbial transformation of desacetylcinobufagin by Fusarium avenaceum AS 3.4594

Zhi-Tu Zhu The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 120001, ChinaCorrespondence[email protected]
View further author information
,
Sha Den School of Pharmacy, Pharmacokinetic and Drug Transport Key Laboratory, Dalian Medical University, Dalian, 116044, ChinaView further author information
,
Yan Wang School of Pharmacy, Pharmacokinetic and Drug Transport Key Laboratory, Dalian Medical University, Dalian, 116044, China
,
Yan-Yan Zhao School of Pharmacy, Pharmacokinetic and Drug Transport Key Laboratory, Dalian Medical University, Dalian, 116044, China
,
Li Wang School of Pharmacy, Pharmacokinetic and Drug Transport Key Laboratory, Dalian Medical University, Dalian, 116044, China
,
Hui-Rang Chen School of Pharmacy, Pharmacokinetic and Drug Transport Key Laboratory, Dalian Medical University, Dalian, 116044, China
&
Dan Liu School of Science, Dalian Nationalities University, Dalian, 116600, ChinaCorrespondence[email protected]
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Pages 294-299 | Received 28 Aug 2012, Accepted 30 Dec 2012, Published online: 19 Feb 2013
 
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Abstract

In this paper, the microbial transformation of desacetylcinobufagin (1) by Fusarium avenaceum AS 3.4594 was investigated, and four metabolites were isolated and characterized as 3-keton-desacetylcinobufagin (2), 3-epi-desacetylcinobufagin (3), bufadienolide A (4), and 15β,16α-dihydroxyl-17βH-bufalin (5), respectively. Among them, 4 and 5 are new compounds. The cytotoxicities of transformed products (2–5) against Hela cells were also investigated.

Acknowledgements

We thank National Natural Science Foundation of China (81274047 and 81202589), Education Department of Liaoning Province (LS2010059) and Program for Liaoning Excellent Talents in University (LJQ2011095) for their financial support.

Notes

1. These authors contributed equally to this work.

Additional information

Notes on contributors

Zhi-Tu Zhu

1

Sha Den

1

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