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Journal of Asian Natural Products Research Volume 15, 2013 - Issue 4
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Original Articles

Two new tri-nor-eudesmanolides from Inula racemosa

Ting Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100020, China
,
Ting Gong State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
,
Ruo-Yun Chen State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, ChinaCorrespondence[email protected]
&
De-Quan Yu State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
Pages 368-372 | Received 22 Nov 2012, Accepted 20 Jan 2013, Published online: 06 Mar 2013
 
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Abstract

Two new tri-nor-eudesmane-type sesquiterpenoids were isolated from the roots of Inula racemosa, and their structures were elucidated as 8-oxo-tri-nor-eudesm-6-en-5α-ol (1) and tri-nor-eudesm-5-en-7β,8β-diol (2). The cytotoxic activity of compound 1 against five human cancer cell lines had been tested, but exhibited no cytotoxic activity.

Acknowledgments

This research program was financially supported by National Science and Technology Project of China (Nos. 2011ZX09307-002-01, 2012ZX09103201-043) and Key Laboratory of Polymorphic Drugs of Beijing.

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