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Journal of Asian Natural Products Research Volume 15, 2013 - Issue 6
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Original Articles

Two new neuroprotective phenolic compounds from Gastrodia elata

Zhen-Chang Zhang Department of Neurology, Second Hospital of Lanzhou University, Lanzhou, 730030, China
,
Gang Su School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China
,
Jiong Li School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China
,
Hua Wu School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China
&
Xiao-Dong Xie School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, ChinaCorrespondence[email protected]
Pages 619-623 | Received 16 Dec 2012, Accepted 27 Mar 2013, Published online: 10 May 2013
 
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Abstract

Two new phenolic compounds 4-(4′-hydroxybenzyl) phenyl glucoside (gastrodin B, 1) and 1′-hydroxymethyl-phenyl 4-hydroxy-3-(4″-hydroxybenzyl) benzyl ether (gastrol B, 2) were isolated from the rhizomes of Gastrodia elata. Their structures were elucidated on the basis of spectroscopic data and chemical reaction. All compounds exhibited potent neuroprotective activity against H2O2-induced PC12 cell damage.

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