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Journal of Asian Natural Products Research Volume 15, 2013 - Issue 6
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Original Articles

Two new cholinesterase inhibitors asiatoates A and B from Buddleja asiatica

Farman Ali Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, Pakistan
,
Hidayat Ullah Khan Department of Biotechnology, University of Science and Technology, Bannu, 28100, KPK, Pakistan
,
Masood Afzal Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, Pakistan
,
Abdul Samad Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, Pakistan
,
Shafi Ullah Khan Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, Pakistan
&
Irshad Ali Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, PakistanCorrespondence[email protected] [email protected]
Pages 631-637 | Received 17 Jan 2013, Accepted 07 Apr 2013, Published online: 10 May 2013
 
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Abstract

Two new benzoates, asiatoate A (1) and asiatoate B (2), have been isolated from the ethyl acetate soluble fraction of Buddleja asiatica whole plant. Their structures were elucidated with the help of spectroscopic data. Both showed significant inhibitory effect on acetylcholinesterase (AChE) and butylcholinesterase (BChE) in a dose-dependent manner. The IC50 values of compounds 1–2 were 5.54 and 8.34 μM against AChE while 30.94 and 35.94 μM against BChE, respectively.

Acknowledgment

The author is thankful to Higher Education Commission of Pakistan for providing financial support under HEC 5000 PhD Indigenous Fellowship Program.

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