Biotransformation of osthole by Alternaria longipes

Abstract

The biotransformation of osthole (1) by Alternaria longipes was carried out, and five transformed products were obtained in the present research work. Based on their extensive spectral data, the structures of these metabolites were characterized as 4′-hydroxyl-osthole (2), 4′-hydroxyl-2′,3′-dihydroosthole (3), 2′,3′-dihydroxylosthole (4), osthole-4′-oic acid methyl ester (5), and osthole-4′-oic acid glucuron-1-yl ester (6), respectively. Among them, products 5 and 6 were new compounds.

Keywords:

• biotransformation
• osthole
• Alternaria longipe
• coumarin

Acknowledgments

We thank the Funding Project of Competence Development Program for Beijing VET Teachers, the Scientific Research Base Fund for Science and Technology Innovation and Transformation Program, and PHR (IHLB201107151) for financial support.

Notes

^1. These two authors contributed equally to this work.

Additional information

Notes on contributors

Xiu-Lan Xin

1 1. These two authors contributed equally to this work.