Two new flavonol glycosides from the Tibetan medicinal plant Aconitum tanguticum

Abstract

Two new flavonol glycosides characterized as quercetin 3-O-α-l-rhamnopyranosyl-(1 → 2)-[β-d-glucopyranosyl-(1 → 3)-α-l-(4-O-trans-p-coumaroylrhamnopyranosyl)-(1 → 6)]-β-d-galactopyranoside-7-O-α-l-rhamnopyranoside (1) and kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 2)-[β-d-glucopyranosyl-(1 → 3)-α-l-(4-O-trans-p-coumaroyl rhamnopyranosyl)-(1 → 6)]-β-d-galactopyranoside-7-O-α-l-rhamnopyranoside (2), together with two known flavonol glycosides quercetin 3-O-α-l-rhamnopyranosyl-(1 → 2)- [α-l-rhamnopyranosyl-(1 → 6)]-β-d-galactopyranoside-7-O-α-l-rhamnopyranoside (3) and kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 → 6)]-β-d-galactopyranoside-7-O-α-l-rhamnopyranoside (4), were isolated from the whole plant of Aconitum tanguticum (Maxim.) Stapf. The structures of the new compounds were elucidated by spectroscopic methods, and the total ¹H and ¹³C NMR chemical shifts were assigned.

Keywords:

• Aconitum tanguticum
• Ranunculaceae
• flavonol glycosides

Acknowledgements

This project was financially supported by Beijing Natural Science Foundation (7132152) and the Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ070828). The authors are grateful to the Department of Instrumental Analysis of Beijing University of Chemical Technology for the NMR measurements.