Two new acridone alkaloids from the branch of Atalantia buxifolia and their biological activity

Abstract

Two new acridone alkaloids, 3-methoxy-1,4,5-trihydroxy-10-methylacridone (1) and 2,3-dimethoxy-1,4,5-trihydroxy-10-methylacridone (2), were isolated from the ethanol extract of the branch of Atalantia buxifolia. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR. Compounds 1 and 2 exhibited significant antibacterial activity against Staphylococcus aureus and weak inhibitory effect on acetylcholinesterase.

Keywords:

• Atalantia buxifolia
• acridone alkaloid
• antibacterial activity
• acetyl cholinesterase inhibitory activity

Acknowledgements

This research was financially supported by the Special Fund for Agro-scientific Research in the Public Interest (201303117) and Fundamental Research Funds for Central Public Welfare Research Institutes (Chinese Academy of Tropical Agricultural Sciences, No. 1630052012014).

Notes

^1. These authors contributed equally to this study.

Additional information

Notes on contributors

Yin-Yu Yang

1 1. These authors contributed equally to this study.